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Routine Peptides
HPLC tested
Representative HPLCPer lot
Kisspeptin research vial

Longevity & Cellular

Kisspeptin

Reproductive Hormone Studies

Third-party testedCOA per lotView COA · 99.08%
$9010mg · $9.00/mg

Quantity

1

Ships from the United States with tracking · free shipping over $200

PassedSterility & Endotoxins
PassedNet Content & Purity
Research use only
Third-party tested
COA with every lot
Tracked shipping

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Certificates of analysis

2 lot certificates for Kisspeptin

Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.

Authenticity

Every vial carries a code

Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.

Verify a batch →

Verified, lot by lot

Per lot
  • Independently tested

    Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.

  • A certificate for your lot

    The report that ships with your order describes the batch you received — not the product line, and not a representative sample.

  • COA-backed replacement

    If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.

  • Tracked dispatch

    Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.

🧬
10
Amino Acids
Decapeptide (KP-10)
🎯
54
Target Receptor
KISS1R high-affinity agonist
⚖️
1302.5
Molecular Weight
C63H83N17O14
⏱️
4 min
Plasma Half-Life
Rapid clearance in vivo

About this compound

What Kisspeptin is

C63H83N17O14

Kisspeptin-10 is the ten-residue active fragment of kisspeptin-54, binding the KISS1R receptor. Its position in the reproductive axis is upstream — it acts on GnRH neurons rather than on the gonads directly — which is what makes it useful for studying the hypothalamic end of hormone regulation.

Formula
C63H83N17O14
Molecular weight
1302.5 g/mol
Form
White lyophilized powder
CAS / ID
374675-21-5
Read the full Kisspeptin research monograph →

Full specification

Molecular weight
1,302.50 g/mol
Molecular formula
C63H83N17O14
Documented purity
Quantified by HPLC, reported per lot

How it works

How Kisspeptin works

The pathways Kisspeptin acts on, and what each one does. Signalling described from preclinical models.

KISS1R / GPR54 Activation

GPR54 Agonist

Binds KISS1R on GnRH neurons in the hypothalamus. The receptor sits upstream of the reproductive axis rather than within the gonads, which is what makes the peptide useful for studying regulation rather than output.

  • Binds KISS1R on hypothalamic GnRH neurons
  • Acts upstream of the gonads, not on them
  • Ten-residue active fragment of kisspeptin-54

GnRH Pulse Generation

GnRH ↑

Activation drives GnRH release in pulses, and the pattern of those pulses — not simply their presence — is what downstream signalling responds to.

  • Drives GnRH release in discrete pulses
  • Pulse pattern carries the downstream signal
  • Measured by frequency as well as amplitude

Gonadotropin Release

LH / FSH ↑

GnRH pulses in turn drive pituitary LH and FSH release. Studying the axis from the top means the whole cascade is observable rather than only its endpoint.

  • LH and FSH released in response to GnRH
  • Whole cascade observable from the top
  • Loss-of-function work established the pubertal role

Uses & applications

What Kisspeptin is researched for

The main areas under study, and the study-reported figures behind them.

Reproductive Neuroendocrinology

GnRH Axis Probing

Acting on GnRH neurons rather than the gonads makes this a tool for interrogating the top of the axis rather than its output.

Fertility Research

Gonadotropin Stimulation

LH and FSH release are measured as the downstream readout of GnRH pulse activity.

Development

Pubertal Signaling

Loss-of-function work in this receptor established its role in pubertal onset, which is where the compound's significance was first recognized.

What the published work measures

The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.

  • LH Pulse Response (animal & human models)
  • KISS1R Receptor Affinity
  • FSH Response

Molecular structure

The Kisspeptin molecule

A computed low-energy conformer built from this compound's published connectivity and stereochemistry, paired with its verified reference values.

Drag to rotate

94 atoms

CON

94 atoms, 98 bonds, C63H83N17O14. Connectivity and stereochemistry from PubChem CID 25240297. The arrangement is one computed low-energy conformer, not a measured structure — a flexible peptide adopts many conformations in solution. Hydrogens omitted for legibility.

C63H83N17O14

Molecular formula
C63H83N17O14
Molecular weight
1302.5 g/mol
Sequence length
10 residues
CAS / ID
374675-21-5
Physical form
White lyophilized powder
Documented purity
Quantified by HPLC, reported per lot

Third-party verified

Independently tested, lot by lot.

Every batch of Kisspeptin is sent to an accredited independent laboratory before it ships. Here is what we screen for.

HPLC purity analysis

Quantifies purity and reports it on the lot certificate

Mass spectrometry

Verifies the exact molecular identity

Heavy metals screening

Lead, arsenic, cadmium & mercury

Endotoxins (LAL)

Bacterial endotoxin levels

Sterility testing

No microbial contamination

Net peptide content

Actual peptide mass per vial verified

FAQ

Common questions about Kisspeptin

What is Kisspeptin?

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Kisspeptin-10 is the ten-residue active fragment of kisspeptin-54, binding the KISS1R receptor. Its position in the reproductive axis is upstream — it acts on GnRH neurons rather than on the gonads directly — which is what makes it useful for studying the hypothalamic end of hormone regulation.

What is Kisspeptin researched for?

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Published research on Kisspeptin concentrates on GnRH Axis Probing, Gonadotropin Stimulation and Pubertal Signaling. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 3 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.

How does Kisspeptin work?

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The literature describes Kisspeptin acting across KISS1R / GPR54 Activation, GnRH Pulse Generation and Gonadotropin Release, reported respectively as GPR54 Agonist, GnRH ↑ and LH / FSH ↑. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.

What are the molecular specifications for Kisspeptin?

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Kisspeptin has a molecular formula of C63H83N17O14 and an average mass of 1302.5 g/mol. It is indexed under CAS 374675-21-5. It ships as white lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.

How should Kisspeptin be stored and reconstituted?

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Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.

Is Kisspeptin approved for human use?

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No. Kisspeptin is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.

Cited sources

Peer-reviewed literature

Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.

  1. [1]Cell BiologyKiSS-1 encodes kisspeptins, natural ligands of GPR54 (opens in a new tab)Kotani M, et al. — J Biol Chem (2001)View source →
  2. [2]ClinicalKisspeptin stimulates the hypothalamic-pituitary-gonadal axis in humans (opens in a new tab)Dhillo WS, et al. — J Clin Endocrinol Metab (2005)View source →
  3. [3]ReviewKisspeptins and reproduction: physiological roles & regulation (opens in a new tab)Pinilla L, et al. — Physiol Rev (2012)View source →

For research use only

Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.

Before you order

Quality Becomes RoutineMeasured. Verified. Documented.

Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.