Research monograph · decapeptide kiss1r/gpr54 agonist
Reproductive Hormone Studies
This monograph collects what the published literature reports about Kisspeptin — its mechanisms, the areas it is studied in, its molecular record and the sources behind them. Its position in the reproductive axis is upstream — it acts on GnRH neurons rather than on the gonads directly — which is what makes it useful for studying the hypothalamic end of hormone regulation.
For laboratory research use only — not for human or animal use
Mechanisms
KISS1R / GPR54 Activation
Binds KISS1R on GnRH neurons in the hypothalamus. The receptor sits upstream of the reproductive axis rather than within the gonads, which is what makes the peptide useful for studying regulation rather than output.
GnRH Pulse Generation
Activation drives GnRH release in pulses, and the pattern of those pulses — not simply their presence — is what downstream signalling responds to.
Gonadotropin Release
GnRH pulses in turn drive pituitary LH and FSH release. Studying the axis from the top means the whole cascade is observable rather than only its endpoint.
Studied applications
Acting on GnRH neurons rather than the gonads makes this a tool for interrogating the top of the axis rather than its output.
LH and FSH release are measured as the downstream readout of GnRH pulse activity.
Loss-of-function work in this receptor established its role in pubertal onset, which is where the compound's significance was first recognized.
What the published work measures
The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.
Reference values
Scroll for full molecular data →
| Molecular weight | 1,302.50 g/mol |
|---|---|
| Molecular formula | C63H83N17O14 |
| Documented purity | Quantified by HPLC, reported per lot |
| Available sizes | 10mg |
FAQ
Kisspeptin-10 is the ten-residue active fragment of kisspeptin-54, binding the KISS1R receptor. Its position in the reproductive axis is upstream — it acts on GnRH neurons rather than on the gonads directly — which is what makes it useful for studying the hypothalamic end of hormone regulation.
Published research on Kisspeptin concentrates on GnRH Axis Probing, Gonadotropin Stimulation and Pubertal Signaling. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 3 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.
The literature describes Kisspeptin acting across KISS1R / GPR54 Activation, GnRH Pulse Generation and Gonadotropin Release, reported respectively as GPR54 Agonist, GnRH ↑ and LH / FSH ↑. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.
Kisspeptin has a molecular formula of C63H83N17O14 and an average mass of 1302.5 g/mol. It is indexed under CAS 374675-21-5. It ships as white lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. Kisspeptin is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed — not Routine Peptides claims.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
