Skip to content
Free shipping over $200FedEx 2-day shipping
Routine Peptides
HPLC tested
Representative HPLCPer lot
Epithalon research vial

Longevity & Cellular

Epithalon

Telomere Lengthening Studies

Third-party testedCOA per lotView COA · 99.753%
$12050mg · $2.40/mg

Quantity

1

Ships from the United States with tracking · free shipping over $200

PassedSterility & Endotoxins
PassedNet Content & Purity
Research use only
Third-party tested
COA with every lot
Tracked shipping

Researchers also added

Kisspeptin

10mg

$90.00

L-Glutathione

1500mg

$120.00

NAD+

500mg

$90.00

Certificates of analysis

2 lot certificates for Epithalon

Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.

Authenticity

Every vial carries a code

Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.

Verify a batch →

Verified, lot by lot

Per lot
  • Independently tested

    Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.

  • A certificate for your lot

    The report that ships with your order describes the batch you received — not the product line, and not a representative sample.

  • COA-backed replacement

    If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.

  • Tracked dispatch

    Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.

🔬
40+
Published Studies
Preclinical & in-vitro papers
🧬
4
Amino Acid Sequence
Ala-Glu-Asp-Gly tetrapeptide
🔬
33%
Telomere Elongation
Cultured human fibroblasts
🎯
4
Research Areas
Cellular Senescence · Circadian & Pineal · Antioxidant Defense & more

About this compound

What Epithalon is

C14H22N4O9

Epithalon is a four-residue peptide derived from epithalamin, a pineal extract studied extensively in Soviet-era research. It is most often examined in the context of telomerase activity and cellular senescence, and much of the primary literature originates from that original research programme rather than from independent replication.

Formula
C14H22N4O9
Molecular weight
390.35 g/mol
Form
Lyophilized Powder
CAS / ID
307297-39-8
Read the full Epithalon research monograph →

Full specification

Molecular weight
390.35 g/mol
Molecular formula
C14H22N4O9
Physical form
Lyophilized Powder
Documented purity
Quantified by HPLC, reported per lot

How it works

How Epithalon works

The pathways Epithalon acts on, and what each one does. Signalling described from preclinical models.

Telomerase Activation & Telomere Biology

Telomerase

Cultured human somatic cell work reports induction of hTERT, the catalytic subunit of telomerase, with telomere length measured as the downstream endpoint. Most of that record traces to a single research programme rather than to independent replication.

  • hTERT expression induced in vitro
  • Telomere elongation in cultured fibroblasts
  • Proliferative lifespan extended in culture

Pineal Peptide Signaling

Pineal / Circadian

Modeled on the pineal extract epithalamin, the peptide has been studied for its influence on melatonin rhythm and circadian regulation — the endpoints its origin would predict.

  • Modeled on the pineal extract epithalamin
  • Melatonin secretion rhythm studied
  • Circadian endpoints measured in animals

Chromatin & Antioxidant Regulation

Gene Expression

Preclinical work describes direct interaction with DNA and altered expression of senescence-associated and antioxidant genes, positioning the peptide as a transcriptional modulator rather than a receptor ligand.

  • Direct peptide-DNA interaction proposed
  • Senescence-associated genes modulated
  • Antioxidant enzyme expression measured in vitro

Uses & applications

What Epithalon is researched for

The main areas under study, and the study-reported figures behind them.

Longevity

Cellular Senescence

Telomerase induction and telomere length are the measured endpoints, mostly in cultured human somatic cells.

Khavinson et al. 2003

Chronobiology

Circadian & Pineal

Melatonin rhythm is studied on the basis of the peptide's origin in pineal extract rather than from a receptor mechanism.

Anisimov et al. 2003

Oxidative Stress

Antioxidant Defense

Antioxidant gene expression is reported to shift, consistent with the transcriptional rather than receptor-mediated framing.

Khavinson 2002

Gerontology

Age-Model Research

Long-duration rodent studies dominate here, and much of the record traces to one research programme rather than independent replication.

Anisimov & Khavinson 2010

What the published work measures

The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.

  • Telomere Length Increase (in vitro)
  • Telomerase Activity (cultured cells)
  • Cell Population Doublings
  • Lipid Peroxidation Reduction

Molecular structure

The Epithalon molecule

The deposited three-dimensional conformer for this compound, paired with its verified reference values.

Drag to rotate

49 atoms

ONCH

49 atoms, 48 bonds, C14H22N4O9. Deposited conformer from PubChem CID 219042, not a drawing.

C14H22N4O9

Molecular formula
C14H22N4O9
Molecular weight
390.35 g/mol
Sequence length
4 residues
CAS / ID
307297-39-8
Physical form
Lyophilized Powder
Documented purity
Quantified by HPLC, reported per lot

Third-party verified

Independently tested, lot by lot.

Every batch of Epithalon is sent to an accredited independent laboratory before it ships. Here is what we screen for.

HPLC purity analysis

Quantifies purity and reports it on the lot certificate

Mass spectrometry

Verifies the exact molecular identity

Heavy metals screening

Lead, arsenic, cadmium & mercury

Endotoxins (LAL)

Bacterial endotoxin levels

Sterility testing

No microbial contamination

Net peptide content

Actual peptide mass per vial verified

FAQ

Common questions about Epithalon

What is Epithalon?

+

Epithalon is a four-residue peptide derived from epithalamin, a pineal extract studied extensively in Soviet-era research. It is most often examined in the context of telomerase activity and cellular senescence, and much of the primary literature originates from that original research programme rather than from independent replication.

What is Epithalon researched for?

+

Published research on Epithalon concentrates on Cellular Senescence, Circadian & Pineal, Antioxidant Defense and Age-Model Research. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.

How does Epithalon work?

+

The literature describes Epithalon acting across Telomerase Activation & Telomere Biology, Pineal Peptide Signaling and Chromatin & Antioxidant Regulation, reported respectively as Telomerase, Pineal / Circadian and Gene Expression. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.

What are the molecular specifications for Epithalon?

+

Epithalon has a molecular formula of C14H22N4O9 and an average mass of 390.35 g/mol. It is indexed under CAS 307297-39-8. It ships as lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.

How should Epithalon be stored and reconstituted?

+

Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.

Is Epithalon approved for human use?

+

No. Epithalon is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.

Cited sources

Peer-reviewed literature

Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.

  1. [1]PubMedPeptide promotes overcoming of the division limit in human somatic cell (opens in a new tab)2003 · Khavinson VKh et al.View source →
  2. [2]PubMedEffect of Epitalon on biomarkers of aging, life span and spontaneous tumour incidence in female CBA mice (opens in a new tab)2003 · Anisimov VN et al.View source →
  3. [3]PubMedEpithalon peptide induces telomerase activity and telomere elongation in human somatic cells (opens in a new tab)2003 · Khavinson VKh et al.View source →
  4. [4]PubMedPineal peptides and aging: gerontological research review (opens in a new tab)2010 · Anisimov VN, Khavinson VKhView source →

For research use only

Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.

Before you order

Quality Becomes RoutineMeasured. Verified. Documented.

Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.