Metabolic & GLP
Inflammation & Neuroprotection Studies
Quantity
Ships from the United States with tracking · free shipping over $200
Certificates of analysis
Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.
Authenticity
Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.
Verify a batch →Independently tested
Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.
A certificate for your lot
The report that ships with your order describes the batch you received — not the product line, and not a representative sample.
COA-backed replacement
If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.
Tracked dispatch
Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.
About this compound
C51H84N16O21
ARA-290, also called cibinetide, is an 11-residue sequence lifted from a single region of erythropoietin. That region is the part of the hormone that engages tissue-protective signaling, and isolating it separates that activity from erythropoietin's effect on red blood cell production. Research interest centers on inflammatory signaling and small-fibre nerve endpoints.
Full specification
How it works
The pathways ARA-290 acts on, and what each one does. Signalling described from preclinical models.
IRR (EPOR/CD131) Agonism
The eleven residues are taken from the helix-B surface of erythropoietin, the region that engages the innate repair receptor. Isolating it selects for tissue-protective signalling and leaves behind the receptor interaction that drives red cell production.
Resolution of Inflammation
Signalling through the innate repair receptor is described as dampening pro-inflammatory activity and actively promoting its resolution, rather than simply suppressing the response.
Cytoprotective & Neuroregenerative Signaling
Receptor activation is reported to engage JAK2/STAT3, PI3K/Akt and anti-apoptotic Bcl-2-family signalling. Small-fibre nerve endpoints are where that cytoprotective activity has been measured most often.
Uses & applications
The main areas under study, and the study-reported figures behind them.
Small-fibre neuropathy in sarcoidosis is the indication with the most developed clinical record for this peptide.
Heij et al. 2012
Corneal confocal microscopy and skin biopsy allow nerve fibre density to be counted directly, which makes these unusually concrete endpoints.
Dahan et al. 2013
Preclinical pain models measure allodynia persistence after dosing stops — a design that tests for durable change rather than symptomatic cover.
Swartjes et al. 2014
The tissue-protective signalling is inherited from erythropoietin, minus the effect on red cell production that the parent hormone carries.
Brines et al. 2008
What the published work measures
The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.
Molecular structure
A computed low-energy conformer built from this compound's published connectivity and stereochemistry, paired with its verified reference values.
Drag to rotate
88 atoms
88 atoms, 88 bonds, C51H84N16O21. Connectivity and stereochemistry from PubChem CID 91810664. The arrangement is one computed low-energy conformer, not a measured structure — a flexible peptide adopts many conformations in solution. Hydrogens omitted for legibility.
C51H84N16O21
Third-party verified
Every batch of ARA-290 is sent to an accredited independent laboratory before it ships. Here is what we screen for.
Quantifies purity and reports it on the lot certificate
Verifies the exact molecular identity
Lead, arsenic, cadmium & mercury
Bacterial endotoxin levels
No microbial contamination
Actual peptide mass per vial verified
FAQ
ARA-290, also called cibinetide, is an 11-residue sequence lifted from a single region of erythropoietin. That region is the part of the hormone that engages tissue-protective signaling, and isolating it separates that activity from erythropoietin's effect on red blood cell production. Research interest centers on inflammatory signaling and small-fibre nerve endpoints.
Published research on ARA-290 concentrates on Sarcoidosis Small-Fiber Neuropathy, Corneal & Skin Nerve Fiber Regrowth, Long-Term Allodynia Relief and EPO-Derived Cytoprotection. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.
The literature describes ARA-290 acting across IRR (EPOR/CD131) Agonism, Resolution of Inflammation and Cytoprotective & Neuroregenerative Signaling, reported respectively as Innate Repair Receptor, Anti-Inflammatory and Tissue Protection. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.
ARA-290 has a molecular formula of C51H84N16O21, an average mass of 1257.3 g/mol and the sequence pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (11 aa). It is indexed under CAS 1208243-50-8. It ships as lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. ARA-290 is sterile or bacteriostatic water; reconstitute by directing the diluent down the vial wall rather than onto the powder, then swirl to dissolve rather than shaking. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. ARA-290 is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.
For research use only
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
