Metabolic & GLP
Inflammation Pathway Studies
Quantity
Ships from the United States with tracking · free shipping over $200
Certificates of analysis
Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.
Authenticity
Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.
Verify a batch →Independently tested
Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.
A certificate for your lot
The report that ships with your order describes the batch you received — not the product line, and not a representative sample.
COA-backed replacement
If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.
Tracked dispatch
Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.
About this compound
C16H30N4O4
KPV is a tripeptide of lysine, proline and valine, corresponding to the C-terminal tripeptide of alpha-MSH. That short tail carries much of the parent hormone's anti-inflammatory signaling while leaving behind its effect on pigmentation, which is the property that made the fragment worth isolating.
Full specification
How it works
The pathways KPV acts on, and what each one does. Signalling described from preclinical models.
Inflammatory Pathway Suppression
Reported to inhibit NF-κB and MAP-kinase signalling at nanomolar concentrations — the transcriptional step upstream of pro-inflammatory cytokine production, rather than the cytokines themselves.
Cellular Transport & Action
Uptake is described via PepT1, an intestinal peptide transporter. That route matters because it lets the tripeptide reach the cell interior, where the signalling it acts on takes place.
Melanocortin Fragment
As the C-terminal tripeptide of alpha-MSH it retains the parent hormone's anti-inflammatory signalling while leaving the pigmentation activity behind. Isolating that fragment is the reason it exists as a separate compound.
Uses & applications
The main areas under study, and the study-reported figures behind them.
Colitis models are the most-studied application, which follows from uptake via an intestinal peptide transporter.
Dalmasso et al. 2008
Inflammatory transcription is the measured endpoint, inherited from the parent hormone minus its pigmentation activity.
Brzoska et al.
Epithelial closure is measured in gut and skin models, where the anti-inflammatory and repair endpoints overlap.
Bonfiglio et al. 2006
Direct antimicrobial effects have been reported, distinct from the anti-inflammatory signalling and less well characterized.
Cutuli et al. 2000
What the published work measures
The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.
Molecular structure
The deposited three-dimensional conformer for this compound, paired with its verified reference values.
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54 atoms
54 atoms, 54 bonds, C16H30N4O4. Deposited conformer from PubChem CID 125672, not a drawing.
C16H30N4O4
Third-party verified
Every batch of KPV is sent to an accredited independent laboratory before it ships. Here is what we screen for.
Quantifies purity and reports it on the lot certificate
Verifies the exact molecular identity
Lead, arsenic, cadmium & mercury
Bacterial endotoxin levels
No microbial contamination
Actual peptide mass per vial verified
FAQ
KPV is a tripeptide of lysine, proline and valine, corresponding to the C-terminal tripeptide of alpha-MSH. That short tail carries much of the parent hormone's anti-inflammatory signaling while leaving behind its effect on pigmentation, which is the property that made the fragment worth isolating.
Published research on KPV concentrates on Intestinal Inflammation & Colitis, α-MSH Anti-Inflammatory Signaling, Epithelial Wound Healing and Antimicrobial Activity. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.
The literature describes KPV acting across Inflammatory Pathway Suppression, Cellular Transport & Action and Melanocortin Fragment, reported respectively as NF-κB Inhibition, PepT1-Mediated Uptake and α-MSH-Derived Activity. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.
KPV has a molecular formula of C16H30N4O4, an average mass of 342.43 g/mol and the sequence L-Lysyl-L-Prolyl-L-Valine (α-MSH 11–13). It ships as lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. KPV is water-soluble; reconstitute by directing the diluent down the vial wall rather than onto the powder, then swirl to dissolve rather than shaking. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. KPV is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.
For research use only
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
