Melanocortin & Tone
Melanocortin Arousal Studies
Quantity
Ships from the United States with tracking · free shipping over $200
Certificates of analysis
Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.
Authenticity
Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.
Verify a batch →Independently tested
Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.
A certificate for your lot
The report that ships with your order describes the batch you received — not the product line, and not a representative sample.
COA-backed replacement
If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.
Tracked dispatch
Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.
About this compound
PT-141, also called bremelanotide, is a cyclic peptide that binds the MC3 and MC4 melanocortin receptors. Its route of action is central rather than vascular — it signals in the nervous system rather than acting on blood flow directly, which distinguishes it mechanistically from other compounds studied for similar endpoints.
How it works
The pathways PT-141 acts on, and what each one does. Signalling described from preclinical models.
Melanocortin Receptor Agonism
Bremelanotide is a cyclic heptapeptide analogue of alpha-MSH that binds several melanocortin receptors, with MC3R and MC4R the subtypes of interest. Cyclisation confers the metabolic stability the linear hormone lacks.
Central Nervous Signalling
Unlike vasoactive compounds studied for overlapping endpoints, activity is described as central rather than peripheral. Published work locates the relevant MC4R populations in hypothalamic nuclei rather than in vascular tissue.
Downstream Neurotransmission
Preclinical models describe melanocortin activation producing downstream changes in dopaminergic signaling in the medial preoptic area, which is the mechanism most often proposed to connect receptor binding to the observed behavioral endpoints.
Uses & applications
The main areas under study, and the study-reported figures behind them.
Used as a pharmacological probe of MC3R and MC4R activity, where its non-selectivity is a study limitation rather than a feature.
Molinoff et al. 2003
Rodent and primate models have measured behavioral endpoints following central melanocortin activation.
Pfaus et al. 2004
Studied across subcutaneous and intranasal administration, with the intranasal route largely abandoned on pharmacokinetic grounds.
Diamond et al. 2004
Binding-affinity work characterizes its activity across the full melanocortin receptor family rather than at a single subtype.
Rosen et al. 2004
Molecular structure
A computed low-energy conformer built from this compound's published connectivity and stereochemistry, paired with its verified reference values.
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74 atoms
74 atoms, 78 bonds, C50H68N14O10. Connectivity and stereochemistry from PubChem CID 9941379. The arrangement is one computed low-energy conformer, not a measured structure — a flexible peptide adopts many conformations in solution. Hydrogens omitted for legibility.
Third-party verified
Every batch of PT-141 is sent to an accredited independent laboratory before it ships. Here is what we screen for.
Quantifies purity and reports it on the lot certificate
Verifies the exact molecular identity
Lead, arsenic, cadmium & mercury
Bacterial endotoxin levels
No microbial contamination
Actual peptide mass per vial verified
FAQ
PT-141, also called bremelanotide, is a cyclic peptide that binds the MC3 and MC4 melanocortin receptors. Its route of action is central rather than vascular — it signals in the nervous system rather than acting on blood flow directly, which distinguishes it mechanistically from other compounds studied for similar endpoints.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. PT-141 is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.
For research use only
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
