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Routine Peptides
HPLC tested
Representative HPLCPer lot
CJC-1295 DAC research vial

Growth Hormone

CJC-1295 DAC

Extended GH Release Studies

Third-party testedCOA per lotView COA · 99.46%
$725mg · $14.40/mg

Quantity

1

Ships from the United States with tracking · free shipping over $200

PassedSterility & Endotoxins
PassedNet Content & Purity
Research use only
Third-party tested
COA with every lot
Tracked shipping

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Certificates of analysis

2 lot certificates for CJC-1295 DAC

Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.

Authenticity

Every vial carries a code

Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.

Verify a batch →

Verified, lot by lot

Per lot
  • Independently tested

    Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.

  • A certificate for your lot

    The report that ships with your order describes the batch you received — not the product line, and not a representative sample.

  • COA-backed replacement

    If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.

  • Tracked dispatch

    Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.

⏱️
8 days
Plasma Half-Life
5.8–8.1 days via albumin binding
📈
10×
GH Elevation
2–10× above baseline for 6+ days
🧬
28 days
IGF-1 Elevation
Maintained above baseline (multi-dose)
🎯
4
Research Areas
Sustained GH Stimulation · Albumin-Depot Mechanism · GHRH Axis Selectivity & more

About this compound

What CJC-1295 DAC is

C152H252N44O42

The DAC variant adds a drug affinity complex — a chemical linker that binds circulating albumin. Because albumin turns over slowly, the linker extends the compound's half-life from minutes into days. That single structural difference is what separates it from standard CJC-1295, and it is the property most research on the compound is built around.

Formula
C152H252N44O42
Molecular weight
3367.97 g/mol
Form
Lyophilized Powder
CAS / ID
863288-34-0
Read the full CJC-1295 DAC research monograph →

Full specification

Molecular weight
3,647.10 g/mol
Molecular formula
C152H252N44O42
Physical form
Lyophilized powder
Documented purity
Quantified by HPLC, reported per lot
Storage
-20°C for up to 24 months
Solubility
Water-soluble

How it works

How CJC-1295 DAC works

The pathways CJC-1295 DAC acts on, and what each one does. Signalling described from preclinical models.

GHRH Receptor Activation

GHRH-R Agonist

A 30-residue GHRH(1–29) analogue carrying four substitutions that block protease cleavage. The receptor interaction matches native GHRH; the substitutions only determine how long the molecule survives to use it.

  • Selective for the GHRH receptor
  • Drives GH synthesis in somatotrophs
  • Pulsatile pattern preserved

Albumin Binding — Half-Life Extension

DAC Technology

The drug affinity complex is a maleimidopropionic acid group at Lys8 that binds circulating albumin after injection. Because albumin turns over slowly, half-life extends from minutes into days — this is the entire difference from the non-DAC version.

  • Binds serum albumin at Cys34
  • Removes the DPP-IV cleavage site
  • Half-life reported ~1,650x native GHRH

Downstream IGF-1 Elevation

IGF-1 Axis

Sustained rather than pulsatile growth hormone exposure drives continuous hepatic IGF-1 production. Whether that steady profile is preferable to a pulsatile one is the open question separating the two variants.

  • IGF-1 reported 1.5-3x above baseline
  • Elevation sustained 9-11 days from one injection
  • 28 days reported on multi-dose protocols

Uses & applications

What CJC-1295 DAC is researched for

The main areas under study, and the study-reported figures behind them.

GH / IGF-1 Axis

Sustained GH Stimulation

The albumin linker turns a minutes-long half-life into days, so exposure is continuous rather than pulsed. That is the variable this compound exists to test.

Teichman et al. 2006

Pharmacokinetics

Albumin-Depot Mechanism

Binding circulating albumin creates a slow-release depot. Because albumin turns over slowly, the peptide is released gradually rather than cleared.

Teichman et al. 2006

Endocrinology

GHRH Axis Selectivity

Activity stays at the GHRH receptor rather than spilling into the ghrelin pathway, which keeps the pituitary's own feedback intact.

Teichman et al. 2006

Animal Models

Growth Normalization

Animal models measure whether sustained upstream stimulation restores growth trajectories, using the non-DAC variant as the comparison.

Alba et al. 2006

What the published work measures

The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.

  • GH Elevation Above Baseline (single dose)
  • IGF-1 Increase (single dose)
  • Half-Life vs Native GHRH
  • GH Elevated Duration (single dose)

Molecular structure

The CJC-1295 DAC molecule

The verified reference values for this compound.

No 3D structure published

This compound is a long, flexible chain. Any single three-dimensional arrangement would be one of an enormous number it can adopt, so we do not show one. The sequence and the reference values beside this are the reliable description.

C152H252N44O42

Molecular formula
C152H252N44O42
Molecular weight
3367.97 g/mol
Sequence length
30 residues
CAS / ID
863288-34-0
Physical form
Lyophilized Powder
Documented purity
Quantified by HPLC, reported per lot

Third-party verified

Independently tested, lot by lot.

Every batch of CJC-1295 DAC is sent to an accredited independent laboratory before it ships. Here is what we screen for.

HPLC purity analysis

Quantifies purity and reports it on the lot certificate

Mass spectrometry

Verifies the exact molecular identity

Heavy metals screening

Lead, arsenic, cadmium & mercury

Endotoxins (LAL)

Bacterial endotoxin levels

Sterility testing

No microbial contamination

Net peptide content

Actual peptide mass per vial verified

FAQ

Common questions about CJC-1295 DAC

What is CJC-1295 DAC?

+

The DAC variant adds a drug affinity complex — a chemical linker that binds circulating albumin. Because albumin turns over slowly, the linker extends the compound's half-life from minutes into days. That single structural difference is what separates it from standard CJC-1295, and it is the property most research on the compound is built around.

What is CJC-1295 DAC researched for?

+

Published research on CJC-1295 DAC concentrates on Sustained GH Stimulation, Albumin-Depot Mechanism, GHRH Axis Selectivity and Growth Normalization. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.

How does CJC-1295 DAC work?

+

The literature describes CJC-1295 DAC acting across GHRH Receptor Activation, Albumin Binding — Half-Life Extension and Downstream IGF-1 Elevation, reported respectively as GHRH-R Agonist, DAC Technology and IGF-1 Axis. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.

What are the molecular specifications for CJC-1295 DAC?

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CJC-1295 DAC has a molecular formula of C152H252N44O42 and an average mass of 3367.97 g/mol. It is indexed under CAS 863288-34-0. It ships as lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.

How should CJC-1295 DAC be stored and reconstituted?

+

Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. CJC-1295 DAC is water-soluble; reconstitute by directing the diluent down the vial wall rather than onto the powder, then swirl to dissolve rather than shaking. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.

Is CJC-1295 DAC approved for human use?

+

No. CJC-1295 DAC is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.

Cited sources

Peer-reviewed literature

Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.

  1. [1]PubMedProlonged stimulation of GH and IGF-I secretion by CJC-1295, a long-acting analog of GHRH, in healthy adults (opens in a new tab)2006 — Teichman SL et al.View source →
  2. [2]PubMedOnce-daily administration of CJC-1295 normalizes growth in the GHRH knockout mouse (opens in a new tab)2006 — Alba M et al.View source →
  3. [3]PubMedDrug Affinity Complex technology: extending peptide half-life via covalent albumin binding (opens in a new tab)2000 — Gagnon C et al. (ConjuChem)View source →
  4. [4]PubMedGHRH analog sermorelin and CJC-1295 pharmacodynamic comparison in GH deficiency models (opens in a new tab)2003 — Frohman LA et al.View source →

For research use only

Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.

Before you order

Quality Becomes RoutineMeasured. Verified. Documented.

Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.