Regenerative & Repair
Cell Migration Studies
Quantity
Ships from the United States with tracking · free shipping over $200
Certificates of analysis
Each certificate covers one production run, and reports on that batch alone. Open any of them to read the laboratory report exactly as the third-party lab issued it.
Authenticity
Scan the code on the label to pull up every published certificate for that compound — the same reports the third-party laboratory issued, batch by batch. Traceable from the laboratory that tested it to your bench.
Verify a batch →Independently tested
Purity is quantified by reverse-phase HPLC and identity confirmed by mass spectrometry, by an outside laboratory rather than in-house.
A certificate for your lot
The report that ships with your order describes the batch you received — not the product line, and not a representative sample.
COA-backed replacement
If material does not match the certificate issued for its lot, we replace it or refund it. Send us the lot number and we will trace it.
Tracked dispatch
Tracking is issued when the label is created, so the shipment is traceable from the moment it leaves us.
About this compound
C212H350N56O78S
TB-500 reproduces the actin-binding region of thymosin beta-4, a protein present in most human cell types. By isolating that region, the fragment retains the parent protein's role in actin sequestration and cell migration in a much smaller molecule. Research covers wound-repair and cell-motility endpoints.
Full specification
How it works
The pathways TB-500 acts on, and what each one does. Signalling described from preclinical models.
Cell Migration & Motility
The fragment binds G-actin monomers and shifts the polymerisation equilibrium, which is what allows a cell to remodel its cytoskeleton and move toward an injury site. Migration is the primary readout in most of the literature because it follows directly from that binding.
Cardiac Repair Signaling
Cardiac models report activation of integrin-linked kinase and migration of cardiac progenitor cells. This arm progressed further clinically than the others, reaching phase II, though the published record remains limited.
Inflammation Modulation
Preclinical work describes reduced pro-inflammatory cytokine expression alongside a shift in macrophage phenotype from inflammatory toward reparative — a change in the character of the immune response rather than its suppression.
Uses & applications
The main areas under study, and the study-reported figures behind them.
Closure rate is the standard readout, following directly from the compound's effect on cell migration.
Malinda et al. 2007
Progenitor cell migration and post-infarct endpoints were measured in the work that progressed furthest clinically.
Bock-Marquette et al. 2004
Corneal epithelial models are unusually clean for migration work, since the tissue is transparent and the repair front can be observed directly.
Sosne et al. 2018
Muscle and connective-tissue endpoints are measured alongside histology, with the actin mechanism as the common thread.
Goldstein et al. 2010
What the published work measures
The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.
Molecular structure
A computed low-energy conformer built from this compound's published connectivity and stereochemistry, paired with its verified reference values.
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62 atoms
62 atoms, 61 bonds, C38H68N10O14. Connectivity and stereochemistry from PubChem CID 62707662. The arrangement is one computed low-energy conformer, not a measured structure — a flexible peptide adopts many conformations in solution. Hydrogens omitted for legibility.
C212H350N56O78S
Third-party verified
Every batch of TB-500 is sent to an accredited independent laboratory before it ships. Here is what we screen for.
Quantifies purity and reports it on the lot certificate
Verifies the exact molecular identity
Lead, arsenic, cadmium & mercury
Bacterial endotoxin levels
No microbial contamination
Actual peptide mass per vial verified
FAQ
TB-500 reproduces the actin-binding region of thymosin beta-4, a protein present in most human cell types. By isolating that region, the fragment retains the parent protein's role in actin sequestration and cell migration in a much smaller molecule. Research covers wound-repair and cell-motility endpoints.
Published research on TB-500 concentrates on Wound Healing, Cardiac Repair, Corneal Healing and Soft Tissue Repair. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.
The literature describes TB-500 acting across Cell Migration & Motility, Cardiac Repair Signaling and Inflammation Modulation, reported respectively as Actin Regulation, Cardiac and Anti-Inflammatory. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.
TB-500 has a molecular formula of C212H350N56O78S and an average mass of 4963.44 g/mol. It ships as lyophilized powder (10mg). Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. TB-500 is water-soluble; reconstitute by directing the diluent down the vial wall rather than onto the powder, then swirl to dissolve rather than shaking. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. TB-500 is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed and peer-reviewed journals — not Routine Peptides claims.
For research use only
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
