Research monograph · synthetic tuftsin-derived heptapeptide
Stress Response Studies
This monograph collects what the published literature reports about Selank — its mechanisms, the areas it is studied in, its molecular record and the sources behind them. Research examines anxiolytic and stress-response endpoints, and much of the primary work sits alongside Semax in the same Russian research literature.
For laboratory research use only — not for human or animal use
Mechanisms
GABA-A Receptor Modulation
Anxiolytic endpoints are attributed to modulation of GABA-A signalling, though the peptide is not a classical benzodiazepine-site ligand and the interaction is described as indirect.
BDNF & Enkephalin Upregulation
Reported increases in BDNF expression and in enkephalin stability connect the peptide to neurotrophic and opioid-adjacent signalling in the same models.
Tuftsin-Derived Immune Regulation
The sequence is built on tuftsin, a naturally occurring immune peptide — which is why immunomodulatory endpoints appear in a literature otherwise concerned with anxiety.
Studied applications
Anxiety-like behavior is measured in standard rodent paradigms, with GABAergic modulation proposed rather than demonstrated.
Semenova et al. 2010
Cognitive endpoints are measured alongside the anxiolytic ones, usually within the same protocol.
Kozlovskaya et al. 2008
Immune endpoints follow from the tuftsin origin and sit oddly alongside an otherwise behavioral literature.
Zozulya et al. 2012
Gene-expression profiling has been used to look for a mechanism the behavioral work could not pin down.
Inozemtseva et al. 2009
What the published work measures
The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.
Reference values
Scroll for full molecular data →
| Sequence | H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH |
|---|---|
| Molecular weight | 751.88 g/mol |
| Molecular formula | C33H57N11O9 |
| Physical form | Lyophilized powder |
| Documented purity | Quantified by HPLC, reported per lot |
| Storage | -20°C for long-term stability |
| Solubility | Water or bacteriostatic water |
| Available sizes | 10mg |
FAQ
Selank is a seven-residue peptide built on tuftsin, a naturally occurring immune peptide, with the same stabilising tripeptide tail used in Semax. Research examines anxiolytic and stress-response endpoints, and much of the primary work sits alongside Semax in the same Russian research literature.
Published research on Selank concentrates on Anxiolytic Mechanisms, Memory & Learning, Cytokine & Immune Modulation and Transcriptomic Studies. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.
The literature describes Selank acting across GABA-A Receptor Modulation, BDNF & Enkephalin Upregulation and Tuftsin-Derived Immune Regulation, reported respectively as GABAergic, Neurotrophin and Immunomodulatory. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.
Selank has a molecular formula of C33H57N11O9, an average mass of 751.88 g/mol and the sequence H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH. It is indexed under CAS 129954-34-3. It ships as lyophilized powder. Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. Selank is water or bacteriostatic water; reconstitute by directing the diluent down the vial wall rather than onto the powder, then swirl to dissolve rather than shaking. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. Selank is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed — not Routine Peptides claims.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
