Research monograph · synthetic pentadecapeptide (15 amino acids)
Tissue Repair Studies
This monograph collects what the published literature reports about BPC-157 — its mechanisms, the areas it is studied in, its molecular record and the sources behind them. It is among the more heavily studied compounds in tissue-repair literature, with animal-model work examining angiogenesis, tendon and ligament endpoints, and gastrointestinal tissue. Sequence stability in gastric conditions is one of the properties that drew attention to it.
For laboratory research use only — not for human or animal use
Mechanisms
Angiogenesis & Vascular Support
Injury models report raised VEGF expression and increased vessel formation at the repair site. Restoring blood supply is the step that gates everything downstream in tissue repair, which is why this arm tends to be measured first.
GHR Upregulation
Tendon fibroblast work reports growth hormone receptor expression rising roughly sevenfold within three days of exposure. The peptide is not supplying growth hormone — it is reported to change how readily the cell responds to what is already there.
Tissue Protection & Repair
Cytoprotective effects are described across several organ systems in animal models, most consistently in gastrointestinal tissue. That is unsurprising given the sequence derives from a protein found in gastric fluid and is stable in that environment.
Studied applications
Tendon-to-bone and ligament models measure fibroblast migration and tensile recovery. This is where most of the musculoskeletal literature sits.
Chang et al. 2014
Mucosal integrity endpoints dominate the earliest work, which follows naturally from the sequence originating in a gastric protein.
Sikiric et al. 2011
A smaller literature examines nerve injury and central endpoints, generally in the same rodent models used for soft tissue.
Sikiric et al. 2016
Vessel formation is measured directly, and it underpins the other three areas — repair elsewhere depends on restored supply.
Sikiric et al. 2019
What the published work measures
The endpoints reported across the literature for this compound. The figures belong to the individual papers, not to us.
Reference values
Scroll for full molecular data →
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
|---|---|
| Molecular weight | 1,419.53 g/mol |
| Molecular formula | C₆₂H₉₈N₁₆O₂₂ |
| Physical form | Lyophilized powder (5mg) |
| Documented purity | Quantified by HPLC, reported per lot |
| Storage | -20°C for long-term stability |
| Solubility | Water-soluble |
| Available sizes | 10mg |
FAQ
BPC-157 is a synthetic 15-residue peptide reproducing a section of a larger protein identified in human gastric fluid. It is among the more heavily studied compounds in tissue-repair literature, with animal-model work examining angiogenesis, tendon and ligament endpoints, and gastrointestinal tissue. Sequence stability in gastric conditions is one of the properties that drew attention to it.
Published research on BPC-157 concentrates on Tendon & Ligament, Gut Protection, Brain & Nervous System and Blood Vessel Repair. Each of those areas is summarised further up this page with the citation it comes from, and the full reference list — 4 indexed publications — sits at the bottom. Study designs and concentrations vary considerably between publications, so the primary sources are worth reading directly.
The literature describes BPC-157 acting across Angiogenesis & Vascular Support, GHR Upregulation and Tissue Protection & Repair, reported respectively as VEGF Pathway, Growth Hormone and Cytoprotective. Those pathways are drawn from preclinical models rather than clinical work, and they describe what has been observed rather than a settled mechanism — the individual pathway cards above cite what each one is based on.
BPC-157 has a molecular formula of C62H98N16O22, an average mass of 1419.53 g/mol and the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It is indexed under CAS 137525-51-0. It ships as lyophilized powder (5mg). Those are nominal reference values for the parent compound. The identity of the specific material you receive is confirmed by mass spectrometry and reported on that lot's certificate.
Store the sealed vial at -20°C, protected from light and moisture, and let it reach room temperature before opening so condensation does not form on cold powder. BPC-157 is water-soluble; reconstitute by directing the diluent down the vial wall rather than onto the powder, then swirl to dissolve rather than shaking. Keep reconstituted solution refrigerated and avoid repeated freeze-thaw cycles — solutions are far less stable than lyophilized powder.
No. BPC-157 is supplied strictly for in-vitro laboratory research and development. It is not a drug, food, supplement or cosmetic, it has not been evaluated by the FDA, and it is not intended for human or animal consumption, ingestion, injection or any in-vivo use. Ordering confirms you are a qualified researcher or institution purchasing on that basis.
Cited sources
Independent published research indexed from PubMed — not Routine Peptides claims.
Before you order
Every production run is analyzed by an independent laboratory, and the certificate for your lot travels with the order — not a catalog-wide document, and not a summary written by us.
